We have lots of thorns here and I don't enjoy changing tubes along the side of the road. So, we use Stan's sealant in both road and mountain bike wheels. The sealant works very well, but requires a removable valve stem core to install.
We like using these 650C tubes with 700C tires/wheels. The reduced size makes them easier for me to install and they are lighter than 700C tubes. Most important, the removable valve cores let you get the sealant into the assembled tire/tube/wheel combination as it dries out and needs to be supplemented after several months in our Arizona "dry heat".
We still get our fair share of punctures from thorns. But, with Stan's sealant in these tubes, very few result in flats. Yeah, you might have to add a little CO2 on the road if you lose too much air due to a puncture, so keep that inflator in your seat bag.
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